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Updated information regarding the most recent in vitro models to study the permeability of drugs Short and concise chapters covering all the biological barriers with interest in drug permeability A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models Simple and clear scientific content, adaptable for young scientists and experimented researchers. Presenting the contributions of internationally known authors, researchers, educators, and practitioners, this new book in the Operations Research Series provides readers with a single source guide to recent developments in this area. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. Ravi Ravindran has been a professor and past department head of Industrial and Manufacturing Engineering at The Pennsylvania State University since The book includes several case studies on the design and operation of supply chain networks in manufacturing and healthcare. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. Each model describes the protocol of seeding and conservation, the application for specific drugs, and takes into account the maintenance of physiologic characteristics and functionality of epithelium, from the simplest immortalized cell-based monoculture to the most complex engineered-tissue models. His post-graduate degrees are from the University of California, Berkeley, where he received a master of science and doctoral degree in industrial engineering and operations research. Covers transportation issues and supply chain inventory decisions in detail Presents multiple criteria mathematical programming models for optimizing decisions regarding the number and location of supply chain facilities and determining optimal distribution strategies Discusses the supplier selection models under multiple conflicting criteria Incorporates supply chain risk as an objective function for designing resilient global supply chains The focus of the book is on the design and operation of the supply chain system, which involves connecting many production and distribution systems, often across wide geographic distances, in such a way that the businesses involved can ultimately satisfy the consumer demand as efficiently as possible, resulting in maximum financial returns to those businesses connected to that supply chain system. Formerly, he was a faculty member in the School of Industrial Engineering at Purdue University for 13 years and at the University of Oklahoma for 15 years. Cell and Tissue Based in CRC Press , 8. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. Ravi Ravindran has been a professor and past department head of Industrial and Manufacturing Engineering at The Pennsylvania State University since Covers transportation issues and supply chain inventory decisions in detail Presents multiple criteria mathematical programming models for optimizing decisions regarding the number and location of supply chain facilities and determining optimal distribution strategies Discusses the supplier selection models under multiple conflicting criteria Incorporates supply chain risk as an objective function for designing resilient global supply chains. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. He also serves as an editorial board member for several international journals and an evaluator of research projects form international agencies. CRC Press , 8.

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Multiple Criteria Decision Making in Supply Chain Management provides a comprehensive overview of multi-criteria optimization models and methods that can be used in supply chain decision making. Updated information regarding the most recent in vitro models to study the permeability of drugs Short and concise chapters covering all the biological barriers with interest in drug permeability A combination of bibliographic information related with individual models and footnote instructions of technical procedures for construction of cell and tissue-based models Simple and clear scientific content, adaptable for young scientists and experimented researchers. The book includes several case studies on the design and operation of supply chain networks in manufacturing and healthcare. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. Concepts and Models for Drug Permeability Studies: Chapters also discuss the equivalence between in vitro cell and tissue models and in vivo conditions, highlighting how each model may provisionally resemble a different drug absorption route. At Oklahoma, he served as the director of the School of Industrial Engineering for eight years and as the associate provost of the university for seven years with responsibility for budget, personnel, and space for the academic area. sfm xxx

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